THE EFFECT OF THE ANTIHISTAMINE CIMETIDINE ON ULTRAVIOLET-RADIATION-INDUCED TUMORIGENESIS IN THE HAIRLESS MOUSE |
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| Authors: | MELISSA J. MATHESON VIVIENNE E. REEVE |
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| Affiliation: | Department of Veterinary Pathology, University of Sydney, NSW, Australia. |
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| Abstract: | This experiment investigated the effect on ultraviolet (UV) radiation-induced tumorigenesis of feeding the histamine type 2 receptor antagonist, cimetidine, to Skh:HR mice. Cimetidine was fed to one group during a 70 day period of chronic UVR (5 days/week for 10 weeks), to a second group from the end of this period to the end of the experiment at 286 days and a third group was fed a control diet only throughout the experiment. Feeding mice cimetidine during the 70 day period of irradiation protected them against the later development of skin tumours. |
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