Catalytic multicomponent reactions for the synthesis of N-aryl trisubstituted pyrroles |
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Authors: | Galliford Chris V Scheidt Karl A |
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Institution: | Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA. |
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Abstract: | Dirhodium(II) salts efficiently catalyze the three-component assembly reaction of an imine, diazoacetonitrile (DAN), and an activated alkynyl coupling partner to form substituted 1,2-diarylpyrroles in moderate to good yields. The transition-metal-catalyzed decomposition of the diazo compound in the presence of the imine presumably generates a transient azomethine ylide that undergoes cycloaddition with dipolarophiles in a highly convergent manner. |
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