Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis |
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| Authors: | Jia Yi-Xia Hillgren J Mikael Watson Emma L Marsden Stephen P Kündig E Peter |
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| Affiliation: | Department of Organic Chemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211, Genea 4, Switzerland. Peter.Kundig@.unige.ch. |
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| Abstract: | The Pd-catalysed asymmetric intramolecular alpha-arylation of amide enolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used. |
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