| Abstract: | The structures of the most important antibacterial glycopeptide antibiotics and the mechanisms of their activity and resistance
to them are examined. Researches on the total synthesis of antibiotics and model compounds are discussed. The chemical modification
of antibiotics (changing the amino acid composition) and also the modification of fragments of the molecule that do not take
part in interaction with the target but make it possible to overcome the resistance of bacteria to antibiotics of this group
are discussed.
Institute of Research into New Antibiotics, RAMN, Moscow, Russia. Translated from Khimiya Geterotsiklicheskikh Soedinenii,
No. 12, pp. 1605–1631, December, 1998. |
