Antibacterial behaviour of quaternized poly(vinyl chloride)-g-poly(4-vinyl pyridine) graft copolymers |
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| Authors: | Madhumita Patel Rajkumar Patel Won Seok Chi Jong Hak Kim Jung-Suk Sung |
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| Affiliation: | 1. Department of Life Science, Dongguk University-Seoul, 3-26 Phil-dong, Chung-gu, Seoul 100-715, South Korea; Department of Chemistry and Nano Science, EwhaWomans University, Global Top 5 Research Program,52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Korea;2. Department of Chemical and Biomolecular Engineering, Yonsei University, 262 Seongsanno,Seodaemun-gu, Seoul 120-749, South Korea;3. Department of Life Science, Dongguk University-Seoul, 3-26 Phil-dong, Chung-gu, Seoul 100-715, South Korea |
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| Abstract: | Amphiphilic graft copolymers consisting of poly(vinyl chloride)(PVC) main chains and poly(4-vinyl pyridine)(P4VP) side chains were synthesized via atom transfer radical polymerization(ATRP) using direct initiation of chlorine atoms. The successful synthesis of PVC-g-P4 VP graft copolymers was confirmed by Fourier transform infrared spectroscopy(FTIR) and proton nuclear magnetic resonance(1H-NMR). Transmission electron microscope(TEM) and small angle X-ray scattering(SAXS) analysis showed that PVC-g-P4 VP exhibited microphase-separated, ordered structure with 37.6 nm of domain spacing, which was not observed in neat PVC. For antibacterial applications, the tertiary nitrogen atoms of PVC-gP4 VP was quaternized using 1-bromohexane, as confirmed by FTIR measurements. Bacteria including Escherichia coli(E. coli), Staphylococcus aureus(S. aureus), Bacillus cereus(B. cereus), and Pseudomonas aeruginosa(P. aeruginosa) were completely killed in 24 h on the quaternized PVC-g-P4VP(46% grafting) surface, indicating its excellent antibacterial behavior while it showed to be cytotoxic to mammalian cell. |
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| Keywords: | Graft copolymer Membranes Atom transfer radical polymerization Antibacterial property Quaternized polymer |
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