Stereoselective synthesis of oxazolidine, hexahydropyrrolo [2,1-b] oxazole, and tetrahydro-2H-oxazolo [3,2-c] thiazole grafted macrocycles through intramolecular 1,3-dipolar cycloaddition reaction |
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| Authors: | S Purushothaman R Raghunathan |
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| Institution: | aDepartment of Organic Chemistry, University of Madras, Chennai 600 025, India |
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| Abstract: | A facile one-pot synthesis of oxazolidine, hexahydropyrrolooxazole and tetrahydro-2H-oxazolothiazole grafted macrocycles through intramolecular 1,3-dipolar cycloaddition reaction (1,3-DC reaction) is reported. X-ray diffraction studies and 2D NOESY experiments of the cycloadducts proved the stereo- and regiochemistry of the cycloaddition. |
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| Keywords: | Macrocycles 1 3-DC reaction Stereoselective Oxazolidine Pyrrolo oxazlole Oxazolothiazole |
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