Oxidation of caffeine with hydrogen peroxide catalyzed by metalloporphyrins |
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Authors: | Clá udia M.B. NevesMá rio M.Q. Simõ es,Isabel C.M.S. SantosFernando M.J. Domingues,M. Graç a P.M.S. Neves,Filipe A. Almeida PazArtur M.S. Silva,José A.S. Cavaleiro |
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Affiliation: | a Department of Chemistry, QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal b Department of Chemistry, CICECO, University of Aveiro, 3810-193 Aveiro, Portugal |
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Abstract: | The biomimetic oxidation of caffeine with hydrogen peroxide using metalloporphyrins as catalysts, which are known to be good biomimetic models of cytochrome P450 enzymes, is investigated. The two manganese porphyrins tested, chloro[5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato]manganese(III), [Mn(TDCPP)Cl], and chloro [5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato]manganese(III), [Mn(TPFPP)Cl], afford high conversions of caffeine for all substrate/catalyst molar ratios. Selectivity was found to be dependent on the catalyst employed, and a new spiro racemic compound is described and fully characterized in the solid state from X-ray diffraction studies. |
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Keywords: | Caffeine Biomimetic oxidation Manganese porphyrins Hydrogen peroxide |
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