An efficient route to chiral alpha- and beta-hydroxyalkanephosphonates |
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| Authors: | Pàmies Oscar Bäckvall Jan-E |
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| Institution: | Arrhenius Laboratory, Department of Organic Chemistry, Stockholm University, SE-10691 Stockholm, Sweden. pamies@organ.su.se |
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| Abstract: | Enzymatic kinetic resolution of alpha- and beta-hydroxyphosphonates in combination with ruthenium-catalyzed alcohol isomerization led to a successful dynamic kinetic resolution. A variety of racemic hydroxyphosphonates were efficiently transformed to the corresponding enantiomerically pure acetates (ee up to 99% and yield up to 87%). |
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