Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase |
| |
| Authors: | Jocelyn D Laughton Philippe Bittar Yves Charnay Luc Pellerin Enikö Kovari Pierre J Magistretti Constantin Bouras |
| |
| Affiliation: | 1.Department of Psychiatry, Service of Neuropsychiatry,University Hospitals of Geneva,Belle-Idée,Switzerland;2.Institute of Physiology, Faculty of Medicine, University of Lausanne,Switzerland;3.Brain and Mind Institute, Ecole Polytechnique Fédérale de Lausanne, University Medical Centre, University of Lausanne,Prilly,Switzerland;4.Center for Psychiatric Neurosciences, Department of Psychiatry,University Medical Centre, University of Lausanne,Prilly,Switzerland;5.Bittar Philippe,spéc. FMH psychiatrie et psychothérapie,Genève,Switzerland |
| |
| Abstract: | Background For a long time now, glucose has been thought to be the main, if not the sole substrate for brain energy metabolism. Recent data nevertheless suggest that other molecules, such as monocarboxylates (lactate and pyruvate mainly) could be suitable substrates. Although monocarboxylates poorly cross the blood brain barrier (BBB), such substrates could replace glucose if produced locally. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
