Synthesis and Stereochemistry of Novel Dibrominated 1,5-Dioxaspiro[5.5]undecane Derivatives |
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| Authors: | Ion Grosu Loïc Toupet Gerard Plé Sorin Mager Eugen Mesaros Andreea Varga Elena Bogdan |
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| Institution: | (1) Babes-Bolyai University, Organic Chemistry Department and CSOFSTM, RO-3400, Cluj-Napoca, Romania, RO;(2) Université de Rennes I, UMR C6626, F-35043 Rennes, France, FR;(3) Université de Rouen et IRCOF, UPRES-A-6014, Faculté des Sciences de Rouen, F-76821 Mont Saint Aignan, France, FR |
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| Abstract: | Summary. The synthesis and stereochemistry of new dibrominated spiro-1,3-dioxane derivatives are reported. Investigations by means
of NMR methods and single crystal X-ray diffraction for two compounds revealed the high regio- and diastereoselectivity of
the bromination reaction of some new spiro-1,3-dioxanes and the asymmetric induction of the chiral carbon atom located in
the spiro skeleton.
Received July 13, 1999. Accepted October 21, 1999 |
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| Keywords: | , ,Spiro compounds, Diastereoselective bromination, X-Ray structure determination, Conformation, NMR Spectroscopy, |
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