Asymmetric synthesis of cyclobutanones: synthesis of cyclobut-G |
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Authors: | Darses Benjamin Greene Andrew E Poisson Jean-François |
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Institution: | Département de Chimie Moléculaire (SERCO) CNRS, UMR-5250, ICMG FR-2607, Université Joseph Fourier BP-53, 38041 Grenoble Cedex 9, France. |
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Abstract: | A simple, efficient, and stereoselective approach has been developed for obtaining chiral cis- and trans-disubstituted cyclobutanones from readily available alkyl- and functionalized alkyl-substituted enol ethers. The usefulness of these cyclobutanones is illustrated by an enantioselective synthesis of cyclobut-G (Lobucavir). |
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