Determination of Sulfaguanidine in Food and Veterinary Pharmaceuticals by Flow Injection Analysis with Spectrophotometric Detection |
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Authors: | Pedro Marcos Frugeri Camila Marchioni Ayla Campos do Lago Célio Wisniewski |
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Institution: | 1. Doutorando em Química Analítica, Universidade Federal de Alfenas (UNIFAL-MG), Instituto de Química, Alfenas, Minas Gerais, Brazil;2. Doutoranda em Química Analítica, Faculdade de Ciências Farmacêuticas de Ribeir?o Preto, Universidade de S?o Paulo (USP-SP), Ribeir?o Preto, S?o Paulo, Brazil;3. Pesquisador do Instituto de Química, Universidade Federal de Alfenas (UNIFAL-MG), Instituto de Ciências Exatas, Alfenas, Minas Gerais, Brazil |
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Abstract: | This work proposes a flow injection analysis system for sulfaguanidine determination in pharmaceutical and food samples. The method was based on the reaction of sulfaguanidine with nitronium ion to produce a colored complex whose absorbance was measured at 545?nm. The flow injection analysis system’s significant parameters were checked by a fractional factorial design 27–2 and optimization by a Doehlert matrix. The flow injection analysis system shows optimum values at 0.28, 2.00, and 0.11% (w/v) for N-naphtil ethylenediamine, ammonium sulfamate, and sodium nitrite concentrations, respectively. The possible interferents present in pharmaceutical and food samples were assessed by a multivariate technique and depicted on probability charts, indicating no significant interferences at the 95% level of confidence interval. The method showed detection and quantification limits of 0.012 and 0.039?mg?L?1, an analytical frequency of 30 readings h?1 and precision always lower than 5.0% expressed as the relative standard deviation. The obtained results were in accordance with those obtained by high-performance liquid chromatography. |
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Keywords: | Chemometry Doehlert matrix flow injection analysis sulfaguanidine |
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