Disposable Stochastic Sensors for the Simultaneous Assay of Acetylcholine and Dopamine in Whole Blood Samples |
| |
| Authors: | Raluca-Ioana Stefan-van Staden Amalia Gabriela Diaconeasa Carmen Cristina Surdu-Bob |
| |
| Institution: | 1. Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, Bucharest, Romania;2. Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, Bucharest, Romania;3. Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, Bucharest, Romania;4. Low Temperature Plasma Laboratory, National Institute for Lasers, Plasma and Radiation Physics (NILPRP), Magurele, Romania |
| |
| Abstract: | Acetylcholine and dopamine are neurotransmitters important for aging and brain pathology. Their assay in whole blood is essential for fast and early detection of neurodegenerative disorders. Therefore, polymeric textile covered with a thin layer of Ag was used to provide stochastic sensors modified with maltodextrins presenting different dextrose equivalence: Maltodextrin I (dextrose equivalence 13.0–17.0), and Maltodextrin II (dextrose equivalence 16.5–19.5). These stochastic sensors were used reliable for both qualitative and quantitative analysis of acetylcholine and dopamine in whole blood samples. Their sensitivity and selectivity were high, and they were reliable for the assay of dopamine and acetylcholine in whole blood samples, with recoveries higher than 98.00%, and relative standard deviations (%) values lower than 1.00%. |
| |
| Keywords: | Acetylcholine disposable stochastic sensors dopamine |
|
|
