Analysis of Solanum Americanum Mill. by Ultrafast Liquid Chromatography with Diode Array and Time-Of-flight Mass Spectrometry Detection with Evaluation of Anti-Inflammatory Properties in Rodent Models |
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| Authors: | Julianna M Vagula Bruno A Rocha Alexandre R Silva Narendra Narain Ciomar A Bersani-Amado Oscar O S Junior |
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| Institution: | 1. Department of Food Chemistry, State University of Maringá, Maringá, Paraná, Braziljuliannamv@hotmail.com;3. Department of Food Chemistry, State University of Maringá, Maringá, Paraná, Brazil;4. Laboratory of Flavor &5. Chromatographic Analysis, Federal University of Sergipe, S?o Cristóv?o, Brazil |
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| Abstract: | Solanum americanum Mill. has been traditionally used for the treatment of fever, stomachache, skin diseases, gynecological disorders, and different kinds of inflammation. This study evaluated the anti-inflammatory response of different extracts obtained from ripe fruits of S. americanum Mill., in experimental models and evaluated them qualitatively using ultrafast liquid chromatography with diode array and time-of-flight mass spectrometry (UFLC-DAD/TOF-MS). The inflammatory response of four extracts of ripe fruits was evaluated for the systemic and topical anti-inflammatory activities. The compounds in each extract were identified using UFLC-DAD-TOF/MS. A total of 34 compounds was identified in the four extracts. The best results were obtained in compounds from the aqueous and chloroform extracts. This study demonstrated a significant anti-inflammatory activity for the compounds present in fruit of S. americanum Mill. |
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| Keywords: | Acute inflammation native plants phenolic compounds solanaceae ultrafast liquid chromatography with diode array and time-of-flight mass spectrometry (UFLC-DAD/TOF-MS) |
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