Enantiomer separation of a novel aminothiazolecarboxamide fungicide using polysaccharide-derived chiral stationary phases

The direct enantioseparation of a novel aminothiazolecarboxamide fungicide, ethaboxam, on polysaccharide-derived chiral stationary phases (CSPs) is described. Good resolution is achieved with several polysaccharide-derived CSPs. Chiralcel OD (OD-H) and Chiralpak AS are excellent for direct enantiomer separation of ethaboxam. The elution behavior and the effects of eluent composition on the resolution of ethaboxam are also investigated. Furthermore, the mechanism for chiral recognition using molecular mechanics is discussed.