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Austrocolorone B and austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini |
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| Authors: | Karren D. Beattie Dion R. ThompsonEvelin Tiralongo David RatkowskyTom W. May Melvyn Gill |
| Affiliation: | a School of Chemistry, The University of Melbourne, Parkville, VIC 3010, Australia b School of Pharmacy, Griffith University, Gold Coast Campus, QLD 4222, Australia c Centre for Phytochemistry and Pharmacology, Southern Cross University, Lismore, NSW 2480, Australia d School of Agricultural Science, University of Tasmania, Hobart, TAS 7001, Australia e Royal Botanic Gardens Melbourne, South Yarra, VIC 3141, Australia |
| Abstract: | The yellow dihydroanthracenone dimer, austrocolorin B1 and the unique violet-red 1,4-anthraquinone dimer, austrocolorone B, were isolated from the Tasmanian mushroom Cortinariusvinosipes and their structures and stereochemistry were determined from spectroscopic data. Austrocolorin B1 and austrocolorone B were found to exhibit potent cytotoxic activity in vitro against the murine lymphoblast (P388D1) cell line with IC50 values in the range 10-31 μg/mL. |
| Keywords: | Cytotoxic Anthraquinone Tricolorin Australian fungi |
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