Antimicrobial Activity and Structural Study of Disubstituted Thiourea Derivatives |
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| Authors: | Silvio Cunha Jr" target="_blank">Fernando C MacedoJr Giselle A N Costa Jr" target="_blank">Manoel T RodriguesJr Rosival B V Verde Lourdes C de Souza Neta Ivo Vencato Carlito Lariucci Fernando P Sá |
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| Institution: | (1) Instituto de Química, Universidade Federal da Bahia, Campus de Ondina, Salvador, BA, Brazil;(2) Ciências Exatas e Tecnológicas, Universidade Estadual de Goiás, Anápolis, GO, Brazil;(3) Instituto de Física, Universidade Federal de Goiás, Goiania, GO, Brazil |
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| Abstract: | Summary. The antimicrobial activity of six N-phenyl- and fourteen N-benzoylthiourea derivatives were evaluated from their Minimal Inhibitory Concentration (MIC) values using the microdilution procedure against ten microorganisms. Most of the compounds exhibited selective activity
against fungi and Gram-positive bacteria, which were very effectively inhibited by some of the tested thioureas. Additionally, SAR considerations and four novel X-ray diffraction structures of N-benzoylthioureas are included. |
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| Keywords: | , Benzoylthioureas, Phenylthioureas, X-ray structure, |
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