Insights on the mechanism for synthesis of methylenedianiline from aniline and formaldehyde through HPLC-MS and isotope tracer studies |
| |
| Authors: | Chen Ye Wanga b Hui Quan Lia Li Guo Wanga Yan Caoa Hai Tao Liua Yi Zhanga a |
| |
| Affiliation: | Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China ; Graduate School of Chinese Academy of Sciences, Beijing 100049, China |
| |
| Abstract: | The mechanism for synthesis of 4,4-methylenedianiline (MDA) via condensation reaction of aniline with formaldehyde has been studied extensively in this paper. The intermediate and by-products were isolated and identified. The combination of isotope labeling and HPLC-MS characterizations disclosed that the reaction proceeded through an SN2 reaction mechanism. Moreover, the effect of aniline/formaldehyde molar ratio on the formation of MDA was investigated. This work would be of significance to understand the reaction mechanism deeply and provide valuable information for further improving the yield of desired product. |
| |
| Keywords: | 4 4-Methylenedianiline Condensation reaction Mechanism HPLC-MS Isotopic tracer |
| 本文献已被 CNKI ScienceDirect 等数据库收录！ |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
|
点击此处可从《中国化学快报》下载全文 |
