| Synthesis and Characterization of Chitosan-grafl-Poly（lactic acid） Copolymer |
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| 引用本文： | 牛旭锋,樊瑜波.Synthesis and Characterization of Chitosan-grafl-Poly（lactic acid） Copolymer[J].高分子科学,2014,32(1):43-50. |
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| 作者姓名： | 牛旭锋 樊瑜波 |
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| 作者单位： | [1]Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China [2]BUAA Research Institute, Guangzhou 510530, China |
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| 基金项目： | This work was financially supported by the National Natural Science Foundation of China （Nos. 11272038, 50803032, 11032012, 10925208, 11202017 and 11120101001）, the Fundamental Research Funds for the Central Universities （No. YWF-13-T-RSC-024）, the 111 Project （No. B13003）, the Intemational Joint Research Center of Aerospace Biotechnology and Medical Engineering, Ministry of Science and Technology of China, and the Program of Pearl River Young Talents of Science and Technology in Guangzhou, China （No. 2013Z2200010）. |
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| 摘 要： | Chitosan-graft-poly(lactic acid)(CS-g-PLA) copolymer was synthesized through emulsion self-assembly in a water-in-oil(W/O) microemulsion. The water phase was composed of CS aqueous solution, while the oil phase was made up of PLA in chloroform. The W/O microemulsion was fabricated in the presence of surfactant span-80 and the self-assembly was performed between PLA and CS under the effect of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride(EDC·HCl). FTIR and1H-NMR analysis indicated PLA was grafted onto the backbone of CS via the reaction between the carboxyl groups in PLA and the amino groups in CS.1H-NMR characterization further revealed the grafting content of PLA was 16%. The obtained CS-g-PLA could self-assemble to form micelles, their size distributed in the range of 125 375 nm with average diameter of 142 nm. The present design integrates the favorable biological properties of CS and the excellent mechanical properties of PLA, which makes CS-g-PLA copolymer a promising candidate as a carrier for targeted bioactive molecules delivery.
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| 关 键 词： | 共聚物 聚乳酸 壳聚糖 表征 合成 自组装法 二甲氨基 表面活性剂 |
Synthesis and characterization of chitosan-graft-poly(lactic acid) copolymer |
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| Xu-feng Niu,Feng Tian,Li-zhen Wang,Xiao-ming Li,Gang Zhou,Yu-bo Fan.Synthesis and characterization of chitosan-graft-poly(lactic acid) copolymer[J].Chinese Journal of Polymer Science,2014,32(1):43-50. |
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| Authors: | Xu-feng Niu Feng Tian Li-zhen Wang Xiao-ming Li Gang Zhou Yu-bo Fan |
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| Institution: | 1. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China
2. BUAA Research Institute, Guangzhou, 510530, China
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| Abstract: | Chitosan-graft-poly(lactic acid) (CS-g-PLA) copolymer was synthesized through emulsion self-assembly in a water-in-oil (W/O) microemulsion. The water phase was composed of CS aqueous solution, while the oil phase was made up of PLA in chloroform. The W/O microemulsion was fabricated in the presence of surfactant span-80 and the self-assembly was performed between PLA and CS under the effect of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC·HCl). FTIR and 1H-NMR analysis indicated PLA was grafted onto the backbone of CS via the reaction between the carboxyl groups in PLA and the amino groups in CS. 1H-NMR characterization further revealed the grafting content of PLA was 16%. The obtained CS-g-PLA could self-assemble to form micelles, their size distributed in the range of 125–375 nm with average diameter of 142 nm. The present design integrates the favorable biological properties of CS and the excellent mechanical properties of PLA, which makes CS-g-PLA copolymer a promising candidate as a carrier for targeted bioactive molecules delivery. |
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| Keywords: | Poly（lactic acid） Chitosan Copolymer Self-assembling Grafting |
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