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Dual Catalysis for the Redox Annulation of Nitroalkynes with Indoles: Enantioselective Construction of Indolin‐3‐ones Bearing Quaternary Stereocenters |
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| Authors: | Dr Ren‐Rong Liu Shi‐Chun Ye Dr Chuan‐Jun Lu Dr Gui‐Lin Zhuang Prof?Dr Jian‐Rong Gao Prof?Dr Yi‐Xia Jia |
| Institution: | College of Chemical Engineering, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014 (China) |
| Abstract: | The enantioselective redox annulation of nitroalkynes with indoles is enabled by gold/chiral phosphoric acid dual catalysis. A range of indolin‐3‐one derivatives bearing quaternary stereocenters at the C2 position were afforded in good yields and excellent enantioselectivities (up to 96 % ee) from readily available starting materials. |
| Keywords: | asymmetric catalysis carbenoids chiral phosphoric acids gold indolinones |