Scalable Synthesis of Piperazines Enabled by Visible‐Light Irradiation and Aluminum Organometallics |
| |
| Authors: | Dr Samuel Suárez‐Pantiga Kilian Colas Dr Magnus J Johansson Dr Abraham Mendoza |
| |
| Affiliation: | 1. Department of Organic Chemistry and Berzelii EXSELENT Center for Porous Materials, Stockholm University, Arrhenius Laboratory, 10691 Stockholm (Sweden) http://www.organ.su.se/am/;2. Innovative Medicines, Cardiovascular and Metabolic Diseases, Medicinal Chemistry, AstraZeneca R&D, Pepparedsleden 1, 43183 M?lndal (Sweden) |
| |
| Abstract: | The development of more active C? H oxidation catalysts has inspired a rapid, scalable, and stereoselective assembly of multifunctional piperazines through a 3+3] coupling of azomethine ylides. A combination of visible‐light irradiation and aluminum organometallics is essential to promote this transformation, which introduces visible‐light photochemistry of main‐group organometallics and sets the basis for new and promising catalysts. |
| |
| Keywords: | aluminum cycloaddition heterocycles oxidation photochemistry |
|
|
