Sodium Salts of Anionic Chiral Cobalt(III) Complexes as Catalysts of the Enantioselective Povarov Reaction |
| |
| Authors: | Dr. Jie Yu Hua‐Jie Jiang Ya Zhou Prof. Dr. Shi‐Wei Luo Prof. Dr. Liu‐Zhu Gong |
| |
| Affiliation: | 1. Department of Applied Chemistry, Anhui Agricultural University (China);2. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China (China);3. Collaborative Innovation Centre of Chemical Science and Engineering, Tianjin (China) |
| |
| Abstract: | The sodium salts of anionic chiral cobalt(III) complexes (CCC?Na+) have been found to be efficient catalysts of the asymmetric Povarov reaction of easily accessible dienophiles, such as 2,3‐dihydrofuran, ethyl vinyl ether, and an N‐protected 2,3‐dihydropyrrole, with 2‐azadienes. Ring‐fused tetrahydroquinolines with up to three contiguous stereogenic centers were thus obtained in high yields, excellent diastereoselectivities (endo/exo up to >20:1), and high enantioselectivities (up to 95:5 e.r.). |
| |
| Keywords: | asymmetric catalysis 2‐azadienes cobalt complexes Povarov reaction tetrahydroquinolines |
|
|
