In Vivo Remote Control of Reactions in Caenorhabditis elegans by Using Supramolecular Nanohybrids of Carbon Nanotubes and Liposomes |
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| Authors: | Dr Eijiro Miyako Dr Svetlana A Chechetka Dr Motomichi Doi Dr Eiji Yuba Prof Kenji Kono |
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| Institution: | 1. Department of Materials and Chemistry, Nanomaterial Research Institute (NMRI), National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1‐1‐1 Higashi, Tsukuba 305‐8565 (Japan);2. Department of Life Science and Biotechnology, Biomedical Research Institute (BRI) & DAILAB, AIST, Central 6, 1‐1‐1 Higashi, Tsukuba 305‐8566 (Japan);3. Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1‐1 Gakuen‐cho, Naka‐ku, Sakai, Osaka 599‐8531 (Japan) |
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| Abstract: | A supramolecular nanohybrid based on carbon nanotubes and liposomes that is highly biocompatible and capable of permeation through cells is described. The nanohybrid can be loaded with a variety of functional molecules and is structurally controlled by near‐infrared laser irradiation for the release of molecules from the nanohybrids in a targeted manner via microscopy. We implemented the controlled release of molecules from the nanohybrids and demonstrated remote regulation of the photoinduced nanohybrid functions. As a proof of principle, nanohybrids loaded with amiloride were successfully used in the spatiotemporally targeted blocking of amiloride‐sensitive mechanosensory neurons in living Caenorhabditis elegans. Our prototype could inspire new designs for biomimetic parasitism and symbiosis, and biologically active nanorobots for the higher‐level manipulation of organisms. |
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| Keywords: | carbon nanotubes controlled delivery liposomes nanotechnology neurons |
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