Utilizing Reversible Interactions in Polymeric Nanoparticles To Generate Hollow Metal–Organic Nanoparticles

The use of reversible linkers in polymers has been of interest mainly for biomedical applications. Herein, we present a novel strategy to utilize reversible interactions in polymeric nanoparticles to generate hollow metal–organic nanoparticles (MOPs). These hollow MOPs are synthesized from self‐assembled polymeric nanoparticles using a simple metal–comonomer exchange process in a single step. The control over the size of the polymer precursor particles translates into a straightforward opportunity for controlling MOP sizes. The shell thickness of the MOPs could be easily tuned by the concentration of metal ions in solution. The underlying mechanism for the formation of these hollow MOPs has been proposed. Evidence for the generality of the method is provided by its application to a variety of metal ions with different coordination geometries.