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Chemically Locked Bicelles with High Thermal and Kinetic Stability |
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| Authors: | Ryoichi Matsui Dr Masataka Ohtani Kuniyo Yamada Dr Takaaki Hikima Prof?Dr Masaki Takata Dr Takashi Nakamura Dr Hiroyuki Koshino Dr Yasuhiro Ishida Prof?Dr Takuzo Aida |
| Institution: | 1. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo 113‐8656 (Japan);2. RIKEN Center for Emergent Material Science, 2‐1 Hirosawa, Wako, Saitama 351‐0198 (Japan);3. RIKEN SPring‐8 Center, 1‐1‐1 Kouto, Sayo, Hyogo 679‐5148 (Japan);4. RIKEN Center for Sustainable Resource Science, 2‐1 Hirosawa, Wako, Saitama 351‐0198 (Japan) |
| Abstract: | In situ polymerization of a bicellar mixture composed of a phospholipid and polymerizable surfactants afforded unprecedented stable bicelles. The polymerized composite showed an aligned phase over a wide thermal range (25 to >90 °C) with excellent 2H quadrupole splitting of the solvent signal, thus implying versatility as an alignment medium for NMR studies. Crosslinking of the surfactants also brought favorable effects on the kinetic stability and alignment morphology of the bicelles. This system could thus offer a new class of scaffolds for biomembrane models. |
| Keywords: | biomembranes phospholipids polymerization surfactants templated synthesis |