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Isoniazid@Fe2O3 Nanocontainers and Their Antibacterial Effect on Tuberculosis Mycobacteria |
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| Authors: | Dr. Peter Leidinger Jens Treptow Kristine Hagens Jacqueline Eich Dr. Nicole Zehethofer Dr. Dominik Schwudke Dr. Wulf Oehlmann Dr. Heinrich Lünsdorf Dr. Oliver Goldmann Prof. Dr. Ulrich E. Schaible Dr. Kurt E. J. Dittmar Prof. Dr. Claus Feldmann |
| Affiliation: | 1. Institut für Anorganische Chemie, Karlsruhe Institute of Technology (KIT), Engesserstrasse 15, 76131 Karlsruhe (Germany);2. Forschungszentrum Borstel, Leibniz‐Zentrum für Medizin und Biowissenschaften, Priority Area Infections, Parkallee 1–40, 23845 Borstel (Germany);3. Lionex—Diagnostics and Therapeutics GmbH, Salzdahlumer Strasse 196, 38126 Braunschweig (Germany);4. Helmholtz‐Zentrum für Infektionsforschung, Inhoffenstrasse 7, 38124 Braunschweig (Germany) |
| Abstract: | Isoniazid‐filled Fe2O3 hollow nanospheres (INH@Fe2O3, diameter <30 nm, 48 wt % INH‐load) are prepared for the first time and suggested for tuberculosis therapy. After dextran‐functionalization, the INH@Fe2O3@DEX nanocontainers show strong activity against Mycobacterium tuberculosis (M.tb.) and M.tb.‐infected macrophages. The nanocontainers can be considered as “Trojan horses” and show efficient, active uptake into both M.tb.‐infected macrophages and even into mycobacterial cells. |
| Keywords: | in vitro studies isoniazid mycobacteria nanocontainers tuberculosis |