Enantioselective ortho‐CH Cross‐Coupling of Diarylmethylamines with Organoborons |
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| Authors: | Dr. Brian N. Laforteza Kelvin S. L. Chan Prof. Dr. Jin‐Quan Yu |
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| Affiliation: | Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037 (USA) |
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| Abstract: | The commonly used para‐nitrobenzenesulfonyl (nosyl) protecting group is employed to direct the C? H activation of amines for the first time. An enantioselective ortho‐C? H cross‐coupling between nosyl‐protected diarylmethylamines and arylboronic acid pinacol esters has been achieved utilizing chiral mono‐N‐protected amino acid (MPAA) ligands as a promoter. |
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| Keywords: | amino acid ligands C H activation C H coupling enantioselective catalysis palladium |
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