Ruthenium‐Catalyzed meta‐Selective CH Bromination |
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| Authors: | Christopher J Teskey Andrew Y W Lui Prof Michael F Greaney |
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| Institution: | School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL (UK) |
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| Abstract: | The first example of a transition‐metal‐catalyzed, meta‐selective C? H bromination procedure is reported. In the presence of catalytic {Ru(p‐cymene)Cl2}2], tetrabutylammonium tribromide can be used to functionalize the meta C? H bond of 2‐phenylpyridine derivatives, thus affording difficult to access products which are highly predisposed to further derivatization. We demonstrate this utility with one‐pot bromination/arylation and bromination/alkenylation procedures to deliver meta‐arylated and meta‐alkenylated products, respectively, in a single step. |
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| Keywords: | bromine C H activation cross‐coupling regioselectivity ruthenium |
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