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Iron‐Catalyzed α‐Alkylation of Ketones with Alcohols |
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| Authors: | Saravanakumar Elangovan Dr. Jean‐Baptiste Sortais Prof. Dr. Matthias Beller Prof. Dr. Christophe Darcel |
| Affiliation: | 1. UMR 6226 CNRS, Université de Rennes 1, Institut des Sciences Chimiques de Rennes, Team “Organometallics: Materials and Catalysis, Centre for Catalysis and Green Chemistry, campus de Beaulieu, 35042 Rennes, Cedex (France);2. Leibniz‐Institut für Katalyse e.V. an der Universit?t Rostock, Albert‐Einstein‐Strasse 29a, Rostock, 18059 (Germany) |
| Abstract: | A general and benign iron‐catalyzed α‐alkylation reaction of ketones with primary alcohols has been developed. The key to success of the reaction is the use of a Knölker‐type complex as catalyst (2 mol %) in the presence of Cs2CO3 as base (10 mol %) under hydrogen‐borrowing conditions. Using 2‐aminobenzyl alcohol as alkylation reagent allows for the “green” synthesis of quinoline derivatives. |
| Keywords: | alkylation borrowing hydrogen homogeneous catalysis Friedlä nder reaction iron catalysts |