Catalytic Decarboxylative Cross‐Coupling of Aryl Chlorides and Benzoates without Activating ortho Substituents |
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| Authors: | Jie Tang Agostino Biafora Prof. Dr. Lukas J. Goossen |
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| Affiliation: | FB Chemie‐Organische Chemie, Technische Universit?t Kaiserslautern, Erwin‐Schr?dinger‐Strasse Geb. 54, 67663 Kaiserslautern (Germany) http://www.chemie.uni‐kl.de/goossen |
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| Abstract: | The restriction of decarboxylative cross‐coupling reactions to ortho‐substituted or heterocyclic carboxylate substrates was overcome by holistic optimization of a bimetallic Cu/Pd catalyst system. The combination of a CuI/Me4phen decarboxylation catalyst and a [(MeCN)4Pd](OTf)2/XPhos cross‐coupling catalyst enables the synthesis of biaryls from inexpensive aryl chlorides and potassium benzoates regardless of their substitution pattern. |
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| Keywords: | aryl chlorides benzoic acids copper cross‐coupling palladium |
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