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Divergent Reactivity of Rhodium(I) Carbenes Derived from Indole Annulations |
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| Authors: | Dr Xiaoxun Li Hui Li Wangze Song Po‐Sen Tseng Dr Lingyan Liu Dr Ilia A Guzei Prof Dr Weiping Tang |
| Institution: | 1. School of Pharmacy, University of Wisconsin‐Madison, Madison, WI 53705‐2222 (USA);2. Institute of Elemento‐Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071 (P.R. China);3. Department of Chemistry, University of Wisconsin‐Madison, Madison, WI 53706 (USA) |
| Abstract: | Rhodium(I) carbenes were generated from propargylic alcohol derivatives as the result of a dehydrative indole annulation. Depending on the choice of the electron‐withdrawing group on the aniline nitrogen nucleophile, either a cyclopropanation product or dimerization product was obtained chemoselectively. Intramolecular hydroamidation occurred for the same type of propargylic alcohol derivatives when other transition‐metal catalysts were employed. |
| Keywords: | carbenes cyclizations heterocycles rhodium synthetic methods |