Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles |
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| Authors: | Xiaojin Wu Chuanhu Lei Guizhou Yue Jianrong Zhou |
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| Affiliation: | 1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore);2. College of Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014 (China) |
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| Abstract: | Many 1,3‐azoles and thiophenes are directly cyclopropylated in the presence of a simple palladium catalyst. The relative configuration on the three‐membered rings is retained in the products. Thus, the cyclopropyl–halide bond undergoes concerted oxidative addition to palladium(0) and cyclopropyl radicals are not involved in the productive pathway. |
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| Keywords: | alkyl halides heterocycles palladium cyclopropane synthetic methods |
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