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| 泽泻醇类化合物与血清白蛋白相互作用的分子机理研究 | |
| 引用本文： | 徐飞,张林群,何立巍,谷巍,房方,吴启南,赵波.泽泻醇类化合物与血清白蛋白相互作用的分子机理研究[J].化学学报,2011,69(19):2228-2234. |
| 作者姓名： | 徐飞 张林群 何立巍 谷巍 房方 吴启南 赵波 |
| 作者单位： | 1. 南京中医药大学,南京,210046 2. 东南大学化学化工学院,南京211189／南京师范大学分析测试中心,南京210097 3. 南京师范大学化学与环境科学学院,南京,210097 |
| 基金项目： | 国家自然科学基金(No.81173483); 江苏省高校自然科学研究计划(No.11KJB360006); 江苏省普通高校研究生科研创新计划(No.CX09B-279Z); 江苏省中医药局行业专项资助课题(No.HZ07041); 南京中医药大学“药用生物资源研究与利用”科技创新团队(2007)资助项目 |
| 摘 要： | 中药泽泻具有抗肿瘤作用,可能与血清中蛋白成分的改变有关.利用荧光光谱、圆二色谱结合分子模拟技术研究了模拟生理条件下泽泻有效成分泽泻醇类化合物与人血清白蛋白的相互作用.实验结果表明,23-乙酰泽泻醇B与蛋白的结合作用远强于24-乙酰泽泻醇A.分子模拟结果与实验一致,并且表明,结合强弱的差异与小分子的侧链结构有关.该结果可... |
| 关 键 词： | 23-乙酰泽泻醇B 24-乙酰泽泻醇A 荧光光谱 圆二色谱 分子模拟 |
Molecular Mechanism on the Interaction between Alisols and Human Serum Albumin |
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| Xu,Feia Zhang,Linqunb,c He,Liweia Gu,Weia Fang,Fanga Wu,Qinan,a Zhao,Bo,d.Molecular Mechanism on the Interaction between Alisols and Human Serum Albumin[J].Acta Chimica Sinica,2011,69(19):2228-2234. | |
| Authors: | Xu Feia Zhang Linqunb c He Liweia Gu Weia Fang Fanga Wu Qinan a Zhao Bo d |
| Institution: | Xu,Feia Zhang,Linqunb,c He,Liweia Gu,Weia Fang,Fanga Wu,Qinan,a Zhao,Bo,d (a Nanjing University of Chinese Medicine,Nanjing 210046) (b School of Chemistry and Chemical Engineering,Southeast University,Nanjing 211189) (c Center for Analysis and Testing,Nanjing Normal University,Nanjing 210097)(d College of Chemistry and Environmental Science,Nanjing 210097) |
| Abstract: | The anti-tumor effect of Traditional Chinese Medicine Alisma may be related to the change of protein components in serum. The molecular interaction mechanism of Alisols with Human Serum Albumin(HSA) was investigated by fluorescence and circular dichroism spectra in combination with molecular mod-eling under the simulated physiological conditions in the paper. Molecular modeling results are in agreement with the experimental results revealed that the binding of Alisol B 23-acetate and HSA was much more stron... |
| Keywords: | alisol B 23-acetate alisol A 24-acetate fluorescence spectra circular dichroism spectra mo-lecular modeling |
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