| 2-氨基-4-噻唑啉酮的高效合成和晶体结构 |
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| 引用本文： | 孟祥武,陆丰平,赵华绒.2-氨基-4-噻唑啉酮的高效合成和晶体结构[J].化学学报,2011,69(19):2281-2286. |
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| 作者姓名： | 孟祥武 陆丰平 赵华绒 |
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| 作者单位： | 1. 浙江大学化学系,杭州,310027
2. 浙江大学化学系,杭州310027／上海艾力斯医药有限公司,上海201204 |
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| 基金项目： | 浙江省自然科学基金(No.Y4080234)资助项目 |
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| 摘 要： | 研究了室温下一锅法高效合成2-氨基-4-噻唑啉酮的绿色方法.在Bmim]SCN体系中,硫氰酸根取代氯乙酸乙酯中的氯可得到2-硫氰酸根乙酸乙酯.而后,在醋酸催化下,通过各种胺对2-硫氰酸根乙酸乙酯的亲核进攻以及中间产物S-烃基异硫脲的关环反应,以较高的产率合成得到2-氨基-4-噻唑啉酮.功能化离子液体Bmim]SCN...
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| 关 键 词： | 噻唑啉酮 合成 功能化离子液体 晶体结构 |
Efficient Synthesis and Crystal Structure of 2-Amino-4-thiazolinones |
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| Meng,Xiangwua Lu,Fengpinga,b Zhao,Huarong,a.Efficient Synthesis and Crystal Structure of 2-Amino-4-thiazolinones[J].Acta Chimica Sinica,2011,69(19):2281-2286. |
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| Authors: | Meng Xiangwua Lu Fengpinga b Zhao Huarong a |
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| Institution: | Meng,Xiangwua Lu,Fengpinga,b Zhao,Huarong,a(a Department of Chemistry,Zhejiang University,Hangzhou 310027)(b Allist Pharmaceuticals,Inc.,Shanghai 201204) |
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| Abstract: | In this paper,a simple,environment-friendly and efficient one-pot way to synthesize 2-amino-4-thiazolinones at room temperature was reported.Ethyl 2-thiocyanatoacetate was formed by sub-stitution reaction of ethyl chloroacetate with thiocyanate in SCN.After that,when HOAc was em-ployed as a catalyst,2-amino-4-thiazolinones were produced in high yields through the nucleophilic attack of amines to ethyl 2-thiocyanatoacetate following ring-closing reaction of intermediate product S-alkyl isothioureas.As a task... |
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| Keywords: | thiazolinones synthesis task-specific ionic liquid crystal structure |
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