| 生物亲和性壳聚糖-二氧化硅复合纳米粒子的合成及其吸附DNA特性研究 |
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| 引用本文： | 张李娜,郭志慧,郑行望,汪绒,孟美荣,屈颖娟,刘全宏,姚莎.生物亲和性壳聚糖-二氧化硅复合纳米粒子的合成及其吸附DNA特性研究[J].化学学报,2011,69(20):2486-2492. |
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| 作者姓名： | 张李娜 郭志慧 郑行望 汪绒 孟美荣 屈颖娟 刘全宏 姚莎 |
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| 作者单位： | 1. 陕西省生命分析化学重点实验室陕西师范大学化学与材料科学学院,西安,710062
2. 陕西师范大学生命科学学院,西安,710062 |
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| 基金项目： | 国家自然科学基金(No.20575040); 国家文物局(No.20090106); 中央高校(No.GK201001007)资助项目 |
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| 摘 要： | 采用反相微乳液法制备了壳聚糖-二氧化硅复合纳米粒子,通过透射电镜（TEM）、红外光谱方法、Zeta电位实验等对所合成的复合纳米粒子的结构和性质等进行了表征.结果显示,基于壳聚糖与silica之间超分子作用所形成的复合纳米粒子呈规则的球形,粒径为50 nm左右,具有良好的单分散性和微孔结构,Zeta电位测定结果表明复合纳...
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| 关 键 词： | 壳聚糖-二氧化硅复合纳米粒子 反相微乳液法 小牛胸腺DNA |
Synthesis of Biocompatible Chitosan-doped SiO_2 Nanoparticles and Its Application for DNA Adsorption |
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| Zhang,Linaa Guo,Zhihuia Zheng,Xingwang,a Wang,Ronga Meng,Meironga Qu,Yingjuana Liu,Quanhongb Yao,Shaa.Synthesis of Biocompatible Chitosan-doped SiO_2 Nanoparticles and Its Application for DNA Adsorption[J].Acta Chimica Sinica,2011,69(20):2486-2492. |
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| Authors: | Zhang Linaa Guo Zhihuia Zheng Xingwang a Wang Ronga Meng Meironga Qu Yingjuana Liu Quanhongb Yao Shaa |
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| Abstract: | A novel mesoporous chitosan-silica nanoparticles was synthesized with the water-in-oil(W/O) reverse microemulsion method.By characterizing this nanoparticles with transmission electron microscopy,IR spectra and the zeta potential experiments,it was found that those nanoparticles were spherical and uni-form with 50 nm size and presented the mesoporous structure.Based on these findings,the adsorption ability of this nanoparticles for calf thymus DNA was studied.The relating results showed that this nanopartic... |
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| Keywords: | chitosan-silica nanoparticles reverse microemulsion calf thymus DNA |
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