| C_（12）C_6C_（12）Br_2/C_（12）E_（10）混合表面活性剂与DNA之间的相互作用 |
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| 引用本文： | 王瑜,曹以诚,韩玉淳. C_（12）C_6C_（12）Br_2/C_（12）E_（10）混合表面活性剂与DNA之间的相互作用[J]. 化学通报, 2011, 0(11): 982-982 |
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| 作者姓名： | 王瑜 曹以诚 韩玉淳 |
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| 作者单位： | 华南理工大学生物科学与工程学院;中国科学院化学研究所胶体界面与化学热力学重点实验室; |
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| 摘 要： | 本文以构建有效的非病毒基因载体为目的,研究了C12C6C12Br2/C12E10混合表面活性剂组成对其与DNA之间相互作用的影响,并对混合表面活性剂与DNA形成的聚集体结构和形貌进行了表征。结果表明,当固定混合表面活性剂的总浓度为1.0 mmol/L时,混合表面活性剂组成的改变会引起混合体系浊度、聚集体表面电荷和聚集体...
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| 关 键 词： | 非离子表面活性剂 阳离子Gemini表面活性剂 DNA |
Interaction between Mixed C_(12)C_6C_(12)Br_2/C_(12)E_(10) Surfactant System and DNA |
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| Wang Yu,Cao Yicheng,Han Yuchun. Interaction between Mixed C_(12)C_6C_(12)Br_2/C_(12)E_(10) Surfactant System and DNA[J]. Chemistry, 2011, 0(11): 982-982 |
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| Authors: | Wang Yu Cao Yicheng Han Yuchun |
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| Affiliation: | Wang Yu1,Cao Yicheng1,Han Yuchun2(1School of Bioscience and Bioengineering,South China University of Technology,Guangzhou 510006 2Beijing National Laboratory for Molecular Sciences,Key Laboratory of Colloid and Interface Science,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190) |
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| Abstract: | To develop an effective non-viral gene delivery system,the interaction between the mixed cationic/nonionic surfactant system(C12C6C12Br2/C12E10) and DNA was studied.The effect of the composition of mixed surfactants on the interaction of C12C6C12Br2/C12E10 with DNA was investigated,and the structure and morphology of complex formed by the mixed surfactants and DNA were characterized.The results showed that the properties of C12C6C12Br2/C12E10-DNA complexes including turbidity,surface charge,and morphologies... |
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| Keywords: | Nonionic surfactant Cationic Gemini surfactant DNA |
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