Simulations of lipid vesicle rupture induced by an adjacent supported lipid bilayer patch |
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Authors: | Allerbo Oskar Lundström Anders Dimitrievski Kristian |
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Institution: | Department of Applied Physics, Chalmers University of Technology, S-412 96 Göteborg, Sweden |
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Abstract: | Using a simple phenomenological model of a lipid bilayer and a surface, simulations were performed to study the bilayer-induced vesicle rupture probability as a vesicle adsorbs adjacently to a bilayer patch already adsorbed on the surface. The vesicle rupture probability was studied as a function of temperature, vesicle size, and surface-bilayer interaction strength. From the simulation data, estimates of the apparent activation energy for bilayer-induced vesicle rupture were calculated, both for different vesicle sizes and for different surface-bilayer interaction strengths. |
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