Development of long-lifetime metal-ligand probes for biophysics and cellular imaging |
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| Authors: | Joseph R Lakowicz Ewald Terpetschnig Zakir Murtaza Henryk Szmacinski |
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| Institution: | (1) Center for Fluorescence Spectroscopy and Medical Biotechnology Center, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard Street, 21201 Baltimore, Maryland |
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| Abstract: | Metal-ligand complexes containing ruthenium, osmium, or rhenium display a high photostability, with polarized emission and
decay times from 100 ns to 100 Μs. Such probes have considerable potential in biophysics, clinical chemistry, and fluorescence
microscopy. In this review we sumrecent developments from this laboratory on the spectral properties of conjugatable metalligand
complexes. We also suggest how improved probes can be developed based on the selection of organic ligands. |
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| Keywords: | Metal-ligand probes biophysics cellular imaging spectral properties |
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