A novel organocatalytic multi-component reaction: an efficient synthesis of polysubstituted pyrano-fused spirooxindoles |
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| Authors: | Zeinab Noroozi TissehFereshteh Ahmadi Minoo DabiriHamid Reza Khavasi Ayoob Bazgir |
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| Affiliation: | Department of Chemistry, Shahid Beheshti University, General Campus, Tehran 1983963113, Iran |
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| Abstract: | A practical, simple, and efficient method for the synthesis of pyrano-fused spirooxindoles via an organocatalytic three-component reaction of isatins, malononitrile, and dialkyl acetylenedicarboxylate in the presence of 3,4-dimethylaniline as an organocatalyst in ethanol is reported. The structures of these products are confirmed by IR, 1H NMR and 13C NMR spectroscopy, mass spectrometry, and single-crystal X-ray diffraction studies. |
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| Keywords: | Spirooxindole Isatin Acetylenic ester Organocatalytic reaction |
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