| A NOVEL VARIANT OF HUMAN INTERFERON α1 GENE |
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| 引用本文： | 黎孟枫,金奇,胡钢,郭辉玉,侯云德.A NOVEL VARIANT OF HUMAN INTERFERON α1 GENE[J].中国科学B辑(英文版),1992(2). |
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| 作者姓名： | 黎孟枫 金奇 胡钢 郭辉玉 侯云德 |
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| 作者单位： | Department of Microbiology&immunology，Immunology，Sun Yat-sen Upiversity of Medical Sciences，Guangzhou 510089，PRC.，Institute of Virology，Chinese Academy of Preventive Medicine，National Laboratory of Molecular Virology and Genetic Engineering，Beijing 100052，PRC，Institute of Virology，Chinese Academy of Preventive Medicine，National Laboratory of Molecular Virology and Genetic Engineering，Beijing 100052，PRC，Institute of Virology，Chinese Academy of Preventive Medicine，National Laboratory of Molecular Virology and Genetic Engineering，Beijing 100052，PRC，Institute of Virology，Chinese Academy of Preventive Medicine，National Laboratory of Molecular Virology and Genetic Engineering，Beijing 100052，PRC |
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| 基金项目： | This work is supported by China National Expert Committee for Biotechnology Development |
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| 摘 要： | A 520-base pair human IFN-α gene was isolated by PCR method twice from chromosome DNA of a Chinese (Han Nationality) fetal liver. The nucleotide sequences were determined. These two separately amplified DNA fragments shared the completely identical nucleotide sequence but possessed C and G at positions 410 and 541, respectively, which differ from those oflFN-α1 and IFN-αD previously described. Therefore the deduced amino acid sequence would have an Ala at position 114 and a Val at position 158. At all other sites it has the same amino acids as those in IFN-α1 and IFN-αD. We recommend that IFN-αD gene, IFN-αI gene and IFN-αI/158V gene found in our laboratory, be named IFN-αla gene, IFN-αlb gene and IFN-αlc gene.
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