Sequential aldol condensation-transition metal-catalyzed addition reactions of aldehydes, methyl ketones, and arylboronic acids |
| |
Authors: | Liao Yuan-Xi Xing Chun-Hui Israel Matthew Hu Qiao-Sheng |
| |
Institution: | Department of Chemistry, College of Staten Island, Staten Island, New York 10314, USA. |
| |
Abstract: | Sequential aldol condensation of aldehydes with methyl ketones followed by transition metal-catalyzed addition reactions of arylboronic acids to form β-substituted ketones is described. By using the 1,1'-spirobiindane-7,7'-diol (SPINOL)-based phosphite, an asymmetric version of this type of sequential reaction, with up to 92% ee, was also realized. Our study provided an efficient method to access β-substituted ketones and might lead to the development of other sequential/tandem reactions with transition metal-catalyzed addition reactions as the key step. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|