Synthesis and antitumoral activity of gelatin/polyoxometalate hybrid nanoparticles |
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Authors: | Guo Rui Cheng Yuan Ding Dan Li Xiaolin Zhang Leyang Jiang Xiqun Liu Baorui |
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Affiliation: | Laboratory of Mesoscopic Chemistry, and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, China. |
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Abstract: | Surfactant-free gelatin/heptamolybdate (HM) hybrid nanoparticles are prepared by a simple and environmentally friendly approach utilizing the electrostatic interaction between anionic HM and the zwitterionic gelatin. The obtained nanoparticles have a tunable size and very high HM loading content up to about 70%. In vitro and in vivo experiments prove that the gelatin/HM hybrid nanoparticles exhibit significantly better antitumor activity than plain ammonium heptamolybdate solution. Therefore, the gelatin/HM hybrid nanoparticles reported here may serve as a prototype platform for polymer/polyoxometalate (POM) hybrid nanoparticles as cancer treatment agents and hence open up more opportunities to maximize the potential of POM-based pharmaceutical agents. |
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Keywords: | antitumor drug delivery systems gelatin nanoparticles polyoxometalates |
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