| A Green Synthesis of 1-Aminoalkyl Phosphonates Under Microwave Irradiation without Any Catalysts and Solvent |
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| 作者姓名： | GU Da-Gong
ZHOU Min-Feng
SHI Hai-Bing
JI Shun-Jun |
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| 作者单位： | GU,Da-Gong（Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006）
ZHOU,Min-Feng（Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006）
SHI,Hai-Bing（Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006）
JI,Shun-Jun（Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006） |
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| 摘 要： | The synthesis of 1-aminoalkyl phosphonates has been developed during past 20 years. 1-Aminoalkyl phosphonates have received much attentions as an important substrate in the synthesis of phosphonopeptides. It is reported that 1-aminoalkyl phosphonates can be used as enzyme inhibitors, antibiotics and pharmacological agents, herbicides and haptens of catalytic antibolies. Many papers mention that synthesis of 1-aminoalkyl phosphonates is convenient by using a base or an acid as a catalyst. For example, Lewis acids such as SnCl2, SnCl4, ZnCl2, MgBr2, INCl3 or acids alumia can be used as a catalyst in this reaction. It is found that the product can be obtained from a mixture of aldehydes, amine and dithyl phosphite under microwave irradiation in yields of 80%～95%.
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A Green Synthesis of 1-Aminoalkyl Phosphonates Under Microwave Irradiation without Any Catalysts and Solvent |
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| GU,Da-Gong,ZHOU,Min-Feng,SHI,Hai-Bing,JI,Shun-Jun.A Green Synthesis of 1-Aminoalkyl Phosphonates Under Microwave Irradiation without Any Catalysts and Solvent[J].Chinese Journal of Organic Chemistry,2004,24(Z1):266. |
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| Authors: | GU Da-Gong ZHOU Min-Feng SHI Hai-Bing JI Shun-Jun |
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| Abstract: | The synthesis of 1-aminoalkyl phosphonates has been developed during past 20 years. 1-Aminoalkyl phosphonates have received much attentions as an important substrate in the synthesis of phosphonopeptides. It is reported that 1-aminoalkyl phosphonates can be used as enzyme inhibitors, antibiotics and pharmacological agents, herbicides and haptens of catalytic antibolies. Many papers mention that synthesis of 1-aminoalkyl phosphonates is convenient by using a base or an acid as a catalyst. For example, Lewis acids such as SnCl2, SnCl4, ZnCl2, MgBr2, INCl3 or acids alumia can be used as a catalyst in this reaction. It is found that the product can be obtained from a mixture of aldehydes, amine and dithyl phosphite under microwave irradiation in yields of 80%～95%. |
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