Hydrogen bonds in carbonylated 1,4-dihydropyridines |
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Authors: | A M Banaru Yu L Slovokhotov |
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Institution: | 1.M. V. Lomonosov Moscow State University,Moscow,Russia |
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Abstract: | For H bonds stabilized by π-conjugation in carbonylated 1,4-dihydropyridines, an analysis of the structural data of the Cambridge
Structural Databank showed that the hydrogen bond was an essential condition for π-conjugation. It was found that π-delocalization
possibly correlated with the bioactivity of drugs that were calcium antagonists. In the presence of two carbonyl groups, hydrogen
bonds in crystal are predominantly formed by the carbonyl group that is anti-periplanar to the 1,4-dihydropyridine ring. |
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