Synthese de polymeres a proprietes pharmacologiques: Introduction de sequence peptidique en chaine laterale

Amino acids have been introduced on to the side-chains of a polymer. Two schemes have been studied: the first involves the synthesis of a monomer containing the amino acid drug moiety and subsequent polymerization; the second depends upon chemical modification of a polymer with the amino acid drug moiety. The drugs used in this study are steroids (cholesterol testosterone). The amino acid moieties introduced on to the side-chains are L-lysine. The preparation of the drug containing the amino acid is done by reacting the chloroformate derivative of the steroid with the amine function of the lysine subsequent to the blocking of the amino acid as a copper complex. The methacrylic monomer is obtained by reacting methacryloyl chloride with the drug amino acid moiety. The polymers were characterized by i.r., NMR (¹H and ¹³C) and GPC. Pharmacological tests are being performed to observe the effect due to the hydrolysis of the drug or the amino acid drug in living organisms.