Highly enantioselective iridium-catalyzed hydrogenation of heteroaromatic compounds,quinolines |
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| Authors: | Wang Wen-Bo Lu Sheng-Mei Yang Peng-Yu Han Xiu-Wen Zhou Yong-Gui |
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| Institution: | Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China. |
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| Abstract: | The highly enantioselective hydrogenation of quinoline derivatives is developed using Ir(COD)Cl]2/(R)-MeO-Biphep/I2 system, and this methodology has been applied to the asymmetric synthesis of three naturally occurring alkaloids angustureine, galipinine, and cuspareine. This method provided an efficient access to a variety of optically active tetrahydroquinolines with up to 96% ee. |
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