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Synthesis of a simplified sarcodictyin analogue which retains microtubule stabilising properties |
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| Authors: | Joachim Telser Raphael Beumer Andrew A Bell Simona M Ceccarelli Diego Monti Cesare Gennari |
| Affiliation: | aDipartimento di Chimica Organica e Industriale, Università di Milano, via G. Venezian 21, I-20133 Milan, Italy bCentro CNR per lo Studio delle Sostanze Organiche Naturali, via G. Venezian 21, I-20133 Milan, Italy |
| Abstract: | A strategy featuring ring-closing metathesis as key reaction is applied to the synthesis of the sarcodictyin analogue 15. The precursor diene is accessed via a brief and efficient protocol, employing multiple stereoselective allylations. Simplified analogue 15 retains microtubule stabilising properties. |
| Keywords: | allylation antitumour compounds metathesis stereocontrol |
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