Efficient enantioselective synthesis of tetramic acids and lactams from threonine |
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| Authors: | Muhammad Anwar |
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| Institution: | University of Oxford, Chemistry Research Laboratory, Department of Chemistry, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom |
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| Abstract: | Regioselective Dieckmann and aldol cyclisations using an N-acyloxazolidine derived from threonine give substituted tetramic acids and pyroglutamates in high yield and enantioselectivity. These are easily deprotected under mild conditions to give products, some of which exhibit antibacterial activity. |
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