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A stereoselective total synthesis of (−)-andrachcinidine via an olefin cross-metathesis protocol |
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| Authors: | Palakodety Radha Krishna G. Dayaker |
| Affiliation: | D-206/B, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | A stereoselective total synthesis of 1-(2S,6R)-6-[(2S)-2-hydroxypentyl]-hexahydro-2-pyridinylacetone, (−)-andrachcinidine is reported. The strategy utilizes olefin cross-metathesis and intramolecular SN2 cyclization as the key steps. |
| Keywords: | Garner&rsquo s aldehyde Hydroboration 1,3-anti Chiral allylation Sharpless asymmetric epoxidation Grubbs&rsquo catalyst Olefin cross-metathesis Intramolecular SN2 cyclization |
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