Diastereoselectively switchable enantioselective trapping of carbamate ammonium ylides with imines |
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| Authors: | Jiang Jun Xu Hua-Dong Xi Jian-Bei Ren Bai-Yan Lv Feng-Ping Guo Xin Jiang Li-Qin Zhang Zhi-Yong Hu Wen-Hao |
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| Institution: | Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China. |
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| Abstract: | The diastereoselectively switchable enantioselective trapping of protic carbamate ammonium ylides with imines is reported. The intriguing Rh(2)(OAc)(4) and chiral Br?nsted acid cocatalyzed three-component Mannich-type reaction of a diazo compound, a carbamate, and an imine provides rapid and efficient access to both syn- and anti-α-substituted α,β-diamino acid derivatives with a high level control of chemo-, diastereo-, and enantioselectivity. |
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